The reference site for Clotrimoxazole

Trimethoprim/sulfamethoxazole (TMP/SMX), also known as co-trimoxazole among other names, is an antibiotic used to treat a variety of bacterial infections.

WHAT IS Clotrimoxazole?

Clotrimoxazole (clotrimazole) is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. Additionally, it is also used to treat athlete’s foot and jock itch.

This medicine works by killing fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As clotrimoxazole (clotrimazole) causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.

 

Brand Name(s): Canesten; Mycelex Troche; Desenex AF;Lotrimin; Lotrisone (combined with betamethasone)
CAS nº: 23593-75-1
(kloe TRIM a zole)

 

Product Info

The sections below will provide you with more specific information and guidelines related to clotrimoxazole (clotrimazole) and its correct use. Please read them carefully.

FDA Information

Clotrimoxazole (clotrimazole) was first approved by the Food and Drug Administration in 1975.

Oral forms of clotrimoxazole continue to be investigated for the treatment of infectious diarrhea and as a unique treatment to block sickling of erythrocytes in sickle cell disease.

This medication is commonly available as an over-the-counter substance in various dosage forms, such as a cream or liquid drops for ears.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Clotrimoxazole (clotrimazole) is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It is also used to treat athlete’s foot and jock itch.

Mechanism of Action:

This medicine kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As clotrimoxazole (clotrimazole) causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.

Other uses for this medicine

Clotrimoxazole (clotrimazole) can also be used to prevent oral thrush in certain patients.

However, it is important that you talk to your doctor or pharmacist about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Clotrimoxazole (clotrimazole) comes as a cream, lotion, and solution to be applied to the skin; lozenges (called troches) to dissolve in the mouth; and vaginal tablets and vaginal cream to be inserted into the vagina.

Clotrimoxazole is usually used five times a day for 14 days for oral thrush, twice a day (in the morning and evening) for 2 to 8 weeks for skin infections, and once a day at bedtime for 3 or 7 days for vaginal infections.

Follow the directions on the package or your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. It is strongly advised that you use clotrimoxazole exactly as directed, and do not use more or less of it – or use it more often – than prescribed by your doctor.

To use the topical cream, lotion, or solution, thoroughly clean the infected area, allow it to dry, and then gently rub the medication in until most of it disappears. Use just enough medication to cover the affected area. You should wash your hands after applying the medication.

The lozenges should be placed in the mouth and dissolved slowly over about 15 to 30 minutes. Do not chew or swallow the lozenges whole.

To use clotrimoxazole vaginal cream or vaginal tablets, read the instructions provided with the medication and follow these steps:

1. Fill the special applicator that comes with the cream to the level indicated or unwrap a tablet, wet it with lukewarm water, and place it on the applicator as shown in the instructions that come with the product.

2. Lie on your back with your knees drawn upward and spread apart.

3. Insert the applicator high into your vagina (unless you are pregnant), and then push the plunger to release the medication. If you are pregnant, insert the applicator gently. If you feel resistance (hard to insert), do not try to insert it further. You should consult your doctor.

4. Withdraw the applicator.

5. Discard the applicator if it is disposable. If the applicator is reusable, pull it apart and clean it with soap and warm water after each use.

6. Wash your hands promptly to avoid spreading the infection.

The vaginal cream or tablets should be applied just before going to bed. The drug works best if you do not get up again after applying it except to wash your hands. You may wish to wear a sanitary napkin while using the vaginal cream or tablets to protect your clothing against stains. Do not use a tampon because it will absorb the drug. Do not douche unless your doctor tells you to do so.

Continue to use clotrimoxazole (clotrimazole) even if you feel well and please do not stop using clotrimoxazole without talking to your doctor. Moreover, make sure you continue using this medication during your menstrual period.

If you obtained the clotrimoxazole skin cream, lotion, or solution without a prescription, use it for 4 weeks for athlete’s foot and 2 weeks for jock itch or body ringworm. If your symptoms do not improve by that time, stop using the medication and consult either a pharmacist or doctor.

What special precautions should I follow?

BEFORE TAKING CLOTRIMOXAZOLE (CLOTRIMAZOLE):

Tell your doctor if you have liver disease. You may not be able to take clotrimoxazole, or you may need a lower dose or special monitoring during treatment.

Since clotrimoxazole is not absorbed by your body, drug interactions are not expected. However, you should talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines.

Oral clotrimoxazole is in the FDA pregnancy category C. This means that it is not known whether clotrimoxazole will harm an unborn baby, therefore you should not take this medication without first talking to your doctor if you are pregnant.

Furthermore, it is not known whether clotrimoxazole will harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Additionally, the safety and effectiveness of clotrimoxazole have not been established for children younger than 3 years of age.

There are no restrictions on foods, beverages, or activities during treatment with clotrimoxazole unless your doctor directs otherwise.

What should I do if I forget a dose?

Take, apply or insert the missed clotrimoxazole (clotrimazole) dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

It is strongly advised that you do not use a double dose to make up for a missed one.

What side effects can this medication cause?

Side effects are not likely to occur with clotrimoxazole (clotrimazole).

However, stop taking clotrimoxazole and seek emergency medical attention if you experience any signs of allergic reaction:

difficulty breathing
closing of your throat
swelling of your lips, tongue, or face
hives

Continue to take clotrimoxazole and talk to your doctor if you experience:

nausea or stomach upset
vomiting
itching
an unpleasant sensation in the mouth

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed. If you have any queries, please do not hesitate to talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

Symptoms of a clotrimoxazole (clotrimazole) overdose are unknown.

However, in the case of a suspected overdose, call your local poison control center on 1-800-222-1222. If the victim has collapsed or is not breathing,  then please call the local emergency services on 911.

Product Images

PICTURES OF CLOTRIMOXAZOLE PILLS

Below you will find images and specific information on the principal types of clotrimoxazole (clotrimazole) that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: MYCELEX TROCHE® LOZENGES
Strength(s): 10 MG
Imprint: MYCELEX 10
Manufacturer: BAYER PHARMACEUTICALS
Distributor: PHYSICIANS TOTAL CARE INC.

Name: CLOTRIMAZOLE
Strength(s): 1 %
Imprint: CLOTRIMAZOLE SOLUTION
Manufacturer: TARO PHARMACEUTICALS

Name: CLOTRIMAZOLE
Strength(s): 1 %
Imprint: CLOTRIMAZOLE SOLUTION
Manufacturer: TEVA PHARMACEUTICALS

Name: CLOTRIMAZOLE
Strength(s): 1 %
Imprint: CLOTRIMAZOLE TOPICAL CREAM
Manufacturer: WARRICK PHARMACEUTICALS

Name: DESENEX®
Strength(s): 1 %
Imprint: DESENEX CREAM
Manufacturer: NOVARTIS

Name: CLOTRIMAZOLE
Strength(s): 1 %
Imprint: CLOTRIMAZOLE TOPICAL CREAM
Manufacturer: TARO PHARMACEUTICALS

Name: CLOTRIMAZOLE 7
Strength(s): 1 %
Imprint: CLOTRIMAZOLE 7-DAY VAGINAL CREAM
Manufacturer: TARO PHARMACEUTICALS

Name: LOTRISONE®
Strength(s): 0.05; 1 %
Imprint: LOTRISONE CREAM
Manufacturer: SCHERING CORP.

Name: CANESTEN®
Strength(s): 1 %
Imprint: CANESTEN CREAM
Manufacturer: BAYER PHARMACEUTICALS

Name: LOTRIMIN®
Strength(s): 1 %
Imprint: LOTRIMIN LOTION USP
Manufacturer: SCHERING CORP.

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